Riboxin is a drug that has anabolic qualities and a minimum of side effects, due to which it is widely used in sports. It increases endurance and stimulates muscle growth, but its main value is in protecting the heart from overload. Let's consider its main properties, rules of administration, as well as how Riboxin is used in sports and bodybuilding to achieve maximum results from strength training.
The drug is prescribed for the treatment of diseases of the heart, liver, eyes, and gastrointestinal tract. Its therapeutic effect is based on the activation of metabolism under conditions of oxygen and ATP deficiency. This quality is very important during anaerobic exercise, characteristic of strength training, which led to the use of Riboxin in sports and bodybuilding.
Compound
1 tablet of the pharmaceutical product contains:
- Riboxin – 0.2 g;
- Calcium stearate;
- Potato starch;
- Powdered sugar;
- Opadry II Yellow coating mixture - Indigo carmine (E 132), Lactose monohydrate, Titanium dioxide (E 171), Macrogol (polyethylene glycol 3000), Quinoline yellow (E 104), Iron oxide (E 172).
Composition of solution for injection:
- Inosine – 20 mg/ml.
Release form
- 2% solution for injection in ampoules of 10 ml (total content of the main active ingredient – 200 mg). The cardboard box holds 10 ampoules.
- tablets are yellow, coated with a biconvex surface. In the cross section, two layers are clearly visible. The drug is packaged in contour cellular blisters made of aluminum foil or PVC, 10 tablets each. A pack contains 1, 2, 3, or 5 plates.
- Riboxin Lect - capsules containing Inosine - 0.2 g. 20, 30 or 50 pieces are placed in a cardboard package.
pharmachologic effect
What is Riboxin?
Riboxin is an anabolic that has nonspecific antihypoxic and antiarrhythmic effects. The main active component of the drug is Inosine (Inosine - INN or international nonproprietary name of pharmaceutical products) - a chemical precursor of adenosine triphosphate (ATP), which is directly involved in the metabolism of glucose and promotes the activation of metabolic processes in conditions of oxygen deficiency (“oxygen starvation”).
Mechanism of action of the drug
The biologically active substances included in the drug activate the metabolism of pyruvic acid (PVA), which ensures the normalization of tissue respiration even in the absence of the required amount of ATP. The active components also affect the enzymatic component of metabolic processes - when they enter the human body, they stimulate the activity of xanthine dehydrogenase , which in turn catalyzes oxidative reactions with the subsequent formation of uric acid from hypoxanthine.
The benefits and harms of Riboxin
The positive effects of the pharmaceutical drug include the effect of the main components of Riboxin on metabolism in the myocardium (heart muscle). Thus, the therapeutic properties of the drug are manifested in an increase in the energy balance of cardiomyocytes , accelerated formation of nucleotides, which manifests itself in enhanced processes of physiological regeneration of cardiac tissue. That is, the medicine helps to normalize the contractile activity of the myocardium and a more complete course of diastole, when the heart completely relaxes due to the ability to bind with chemical chains of calcium ions that penetrate into the intracellular space during systole.
The negative effects of Riboxin include a change in the physiological sequence of the metabolic cycle . That is, the active components of a pharmaceutical drug, coming from outside, make adjustments to metabolic processes. As a rule, qualified specialists try, if possible, not to interfere in this area of biochemistry of the human body, since therapeutic effects can cause very adverse consequences for the patient. However, in the presence of a pathological process that destructively affects the heart muscle (the vital “pump” of the circulatory system), a change in metabolism is necessary, because non-intervention will lead to a much worse outcome.
Wikipedia about Riboxin
The free encyclopedia of knowledge on the Internet also reveals some aspects of the pharmacological action of the drug. In particular, all the cardiac effects of the biologically active components that make up Riboxin are described. In addition, on the page about this medicine there is information about the effect on the cellular component of the blood coagulation system - Inosine reduces platelet aggregation, which reduces the risk of developing thrombosis and thromboembolism . The regenerative therapeutic properties of the pharmaceutical drug extend not only to the heart muscle, but also to the mucous membrane of the gastrointestinal tract.
Separately, it should be noted that Inosine pranobec s is a type of drug that has immunostimulating activity and a nonspecific antiviral effect. The drug suppresses such harmful pathogens as herpes simplex virus, CMV (cytomegalovirus), measles and T-cell lymphoma virus type 3, human enterocytopathogenic virus and many others. The mechanism of this action lies in the inhibition of ribonucleic acid and inhibition of the biological catalyst dihydropteroate synthetase, which manifests itself in the suppression of viral replication and increased production of interferons by lymphocytes that destroy pathological organisms.
Effect of the drug
The drug Riboxin can improve blood flow in individual internal organs, which increases the delivery of nutrients and oxygen to them, activating intracellular metabolic processes.
Thanks to this, biological tissue receives additional energy and can withstand unwanted influences. Hypoxia, i.e. lack of oxygen is observed in people under various conditions, for example, during pregnancy, in patients with diseases of the lungs and cardiovascular system. In these cases, the drug allows you to cope with hypoxia and restore the normal functioning of internal organs.
Pharmacological properties of Riboxin
If the patient is forced to remain immobile for a long time (rehabilitation after spinal column injuries, long postoperative period, etc.), then the use of medication in the form of droppers and injections will restore nutrition to immobilized parts of the body.
This property of the drug is associated with its ability not only to improve the nutrition of biological tissues, but also to prevent the formation of microthrombi in the vascular bed.
In this regard, the drug is widely used in clinical practice for various diseases.
It is important to note that the medicine helps patients of all ages and can be used for both men and women
Auxiliary components include various salts and, in the case of the injection form, purified water. Such additives allow you to preserve the active substance in its active form and prevent its destruction.
Action of inosine
The main active ingredient of the drug is Inosine, which belongs to the group of ATP precursors (adenosine triphosphate). This component is capable of stimulating metabolic processes inside cells, as well as providing a pronounced protective effect against hypoxic damage and arrhythmias.
Inosine in capsules, tablets or injections improves the processes of tissue respiration, which determines its biological effects on the human body.
Pharmacodynamics and pharmacokinetics
When taken orally, Riboxin is well and almost completely absorbed from the gastrointestinal tract. When administered intravenously, the pharmaceutical drug is quickly distributed into tissues that need ATP. Regardless of the route of administration, unused active ingredients are metabolized in the liver, where the final stages of metabolic biochemical reactions take place. A small amount of Riboxin is excreted in urine, feces and bile.
Indications for use of Riboxin
Indications for use of Riboxin tablets:
- Complex treatment of coronary heart disease (angina pectoris, coronary insufficiency, condition after myocardial infarction);
- Intoxication with cardiac glycoside drugs;
- Cardiomyopathies of various origins;
- Myocarditis;
- Rheumatic, congenital and acquired heart defects;
- Cardiac arrhythmia;
- Myocardial dystrophy of infectious or endocrine origin (especially against the background of heavy physical exertion);
- Coronary atherosclerosis ;
- Nonspecific liver diseases ( hepatitis , fatty degeneration of the parenchymal organ, cirrhosis);
- Drug and alcohol liver damage;
- Urocoproporphyria;
- Prevention of a decrease in the number of leukocytes during irradiation;
- Peptic ulcer of the stomach and duodenum ;
- Open-angle glaucoma with normalized intraocular pressure.
Specific indications for the use of injections:
- Urgent pathological conditions of cardiac arrhythmia;
- Surgeries on an isolated kidney (as a means of pharmacological protection in case of temporary absence of blood circulation);
- Arrhythmias of unknown etiology in medicine;
- Acute radiation exposure to prevent the development of changes in the blood formula.
Side effects
As a rule, the medicine is well tolerated, only in isolated cases the following side effects are observed:
- Arterial hypotension;
- Increased levels of uric acid and its salts in the blood;
- Tachycardia;
- Itchy skin;
- General weakness;
- Exacerbation of gout;
- Urticaria of allergic origin;
- Redness of the skin.
Instructions for use of Riboxin (Method and dosage)
Riboxin tablets, instructions for use
Tablets are used orally , before meals. The dosage, as a rule, is set individually in view of the characteristics of the metabolism of the active components and indications for conservative therapy. However, there are certain general treatment regimens for this pharmaceutical drug, according to which the daily dose for adults and children over 12 years of age is 0.6-2.4 g per day. Sanitation begins with small dosages (about 0.6-0.8 g - 1 tablet 3-4 times a day), and then, if the medicine is well tolerated and has a beneficial effect on the body, the dose is gradually increased over 2-3 days .
The maximum amount of the drug taken is 2.4 g per day - 4 tablets 3 times per day. This dosage is achieved for 2 months of a course of conservative treatment, the entire duration of which, as a rule, lasts from 1 to 3 months and is adjusted taking into account individual indications for therapeutic intervention.
Separately, it should be noted how to take tablets for urocoproporphy , since the pathophysiology of this disease is associated with an increase in uric acid salts in biological fluids and secretions. Riboxin, in turn, accelerates the metabolism of urates, activating the enzymatic oxidation of hypoxanthine. Therefore, in order to avoid deposits and the formation of stones, the dosage of the drug is 0.8 g per day - 1 tablet 4 times a day and must be strictly observed during conservative treatment.
Riboxin injections, instructions for use
Slow drip parenteral administration or rapid jet injections , depending on individual indications and the urgency of the pathological condition. If the attending physician chooses injections, then first apply a minimum dosage of 200 mg of Riboxin (10 ml of 2% injection solution) once a day. In case of acute cardiac arrhythmias, a single injection of 200-400 mg of Inosine (10-20 ml of 2% solution) intravenously can be used.
The dosage of jet administration is increased only if the drug is well tolerated. The maximum amount of the drug can be 400 mg of Riboxin (two ampoules of a 2% solution) 1 or 2 times a day. The duration of the course is selected individually (according to the general protocol - 10-15 days).
If you use Riboxin intravenously (intravenously) , then before its administration, a 2% solution of the drug must be diluted in 5% glucose or hypotonic sodium chloride solution (concentration - 0.9%) to obtain 250 ml of medicinal liquid. The rate of administration is 40-60 drops per minute.
Instructions during pregnancy
Riboxin is used intravenously for pregnant women, because in this way its effects are revealed more fully. The dosage and duration of the course of conservative therapy is selected strictly individually in each individual case, based on the results of various clinical studies and the opinion of qualified specialists.
How to use Riboxin Lect?
The dosage and duration of treatment with this variation of the pharmaceutical drug do not differ from the generally accepted protocols for therapeutic care with Riboxin. However, the Lect form of the drug is not used as an emergency correction of dysfunction of the heart muscle or other organs, since its effects develop somewhat more slowly.
Are there analogues
Today you can find a large number of different analogues of Riboxin tablets in pharmacies. Analogues are considered to be products that contain similar active substances and also have a similar therapeutic effect on the body.
So, most often doctors prescribe to their patients such substitutes for the drug “Riboxin”, such as: “Cavinton”, “Esculex”, “Magnerot”, “Heparin”, “Capoten”, and many others.
Do not self-medicate under any circumstances. Despite the fact that the drugs listed above are intended to generally improve health indicators, they must be taken with extreme caution, because each of them has its own contraindications, so they simply may not be suitable for you.
Interaction
The combined use of a drug with cardiac glycosides enhances the inotropic effect of the latter and prevents the development of such adverse consequences of drug treatment as the occurrence of arrhythmia, for which Riboxin is sometimes prescribed together with this group of pharmaceuticals.
Simultaneous use of Riboxin with anticoagulants such as heparin increases the duration of their therapeutic action.
The drug is completely incompatible with acids and alcohols , pyridoxine hydrochloride or vitamin B6 , since both chemical compounds are deactivated, salts of heavy metals , and plant alkaloids . The latter, when interacting with Riboxin, form insoluble and non-removable compounds due to the detachment of the alkaloid base.
Contraindications
- Hyperuricemia;
- Gout;
- Pregnancy and breastfeeding period;
- Sucrase/isomaltase deficiency, galactose/glucose malabsorption syndrome and fructose intolerance (for tablets and capsules);
- Children and adolescents under 18 years of age (since the safety and effectiveness of the drug have not been established);
- Hypersensitivity to the main or auxiliary components of the drug.
Riboxin is prescribed with caution to patients with diabetes mellitus and renal failure.
special instructions
Riboxin in bodybuilding
The pharmaceutical drug is classified as a metabolic agent and biochemical stimulant, so the drug can be used to gain weight , improve physical performance and increase strength . Riboxin was actively used in sports back in the 70s. The following types of nutrition for bodybuilders are known, which are actively sold to this day:
- Premium Inosine;
- Ultimate nutrition;
- Inosine mega-pro;
- Inosine life extension;
- Cell-tech hardcore.
How to take Riboxin for bodybuilding?
In sports nutrition, a tablet form of the drug is used, which is administered orally before meals. The dosage ranges from 1.5 to 2.5 g per day. As for therapeutic purposes, the number of tablets taken should be gradually increased from a starting dosage of 0.6-0.8 g 3-4 times a day to 2.5 g. Riboxin for athletes should be used for 4 weeks to 1.5 -3 months.
To enhance the effect of the drug on the myocardium and reduce the period of mid-mountain and climatic adaptation, Potassium orotate and Riboxin can be used together. In this case, the dosage of the potassium salt of orotic acid is 0.25-0.5 g 2-3 times a day before meals (course duration is 15-30 days), and Riboxin is used according to the above scheme.
Riboxin in veterinary practice
The drug is non-specific in its pharmaceutical nature, therefore it can also be used in veterinary therapeutic practice. Often the drug is used for dogs to eliminate heart failure , treat myocarditis and endocarditis , improve the metabolic abilities of the muscular organ with myocardosis and heart defects , which are very common senile problems in animals.
How should animals take Riboxin?
As a rule, the drug is administered intramuscularly , because this is the most rational route of administration in veterinary practice. The dosage is 0.1-0.2 g of the drug per 10 kg of animal weight 3 times a day. The course of conservative treatment lasts about a month. Repeated prescriptions of Riboxin are possible for a more thorough correction of metabolism or elimination of deep degenerative changes.
When is the drug used?
In medicine, the drug is used in the treatment of:
- Liver after alcohol intoxication
- Stomach
- Duodenum
- Hearts
It will be of great benefit after using anabolic steroids, and can also be taken together with steroids. Used in the treatment of glaucoma, which improves vision function. In bodybuilding, the drug will help with sprains and is well suited for strengthening the walls of blood vessels and capillaries.
There is even an opinion, which not many people agree with, that Riboxin can be called one of the best anabolic drugs. But if we consider all the drugs that are non-hormonal and non-steroidal, then it is among the first drugs for bodybuilding.
https://www.youtube.com/watch?v=Ok0wQZOrOp0
Back in Soviet times, weightlifters used this medicine very effectively, but later they abandoned this drug, since studies did not prove the need for this medicine in sports. For visible results, it is best to add B vitamins, orotate and glycerophosphate to Riboxin. Moreover, this scheme is suitable for “chemists” and those who prefer everything natural.
It can also be considered an excellent creatine substitute, at a lower price. Side effects include only personal intolerance, otherwise it is considered completely safe. If you are personally intolerant, an allergic rash may appear. The main thing is to maintain the correct proportions and not to overuse quantities.
Riboxin during pregnancy (and lactation)
The pharmaceutical drug is actively prescribed during the most critical periods for a woman, which, as a rule, plunges expectant mothers into slight bewilderment. Even after reading the instructions, many questions remain, the main one of which, of course, is what Riboxin is for during pregnancy. The drug improves energy supply and tissue metabolism , that is, it provides the woman and fetus with a more active supply of beneficial nutrients during the period when they suffer from deficient conditions. This is one of the main aspects of using Riboxin.
Also, the active ingredients help reduce harm from the so-called “ oxygen starvation ,” which is a common complication during pregnancy. A pathological condition occurs because the woman’s respiratory system supplies two organisms with vital gas. But such a powerful need for oxygen runs counter to the capabilities of the lungs and bronchial tree. Therefore, the antihypoxic effect of Riboxin comes in handy, and this is the second, but no less important aspect of using the drug during pregnancy.
Among the therapeutic properties of a pharmaceutical drug, a significant part consists of effects on cardiac activity . Riboxin normalizes myocardial contractile activity, regulates the metabolic needs of cardiomyocytes, and helps enhance trophic processes. Thus, the drug plays the role of preventive sanitation , since it is not uncommon for pregnant women to develop pathological processes such as arrhythmias, tachycardias and other disturbances in the rhythm of the heart muscle.
How to take Riboxin for pregnant women?
The dosage and duration of use of a pharmaceutical drug during pregnancy is always selected individually based on diagnostic test results, ultrasound data and other physiological parameters. As a rule, Riboxin is administered intravenously during pregnancy, but in the medical literature and on thematic forums for pregnant women, cases of prescribing the tablet form of the drug are described.
Impact on the body of athletes
Athletes taking Riboxin have an activated metabolism and, thanks to this, a lack of oxygen during exercise does not cause discomfort. A positive effect is observed on the heart muscle, which is important during physical activity, especially in bodybuilding and powerlifting.
The product actively participates in the metabolic process of glucose in the body, oxidative and reduction processes, and improves tissue respiration. By increasing the force of contractions of the heart muscle, it promotes relaxation of the myocardium, improves blood circulation and blood supply to tissues.
The use of the product prevents the sticking of platelets (which leads to the formation of blood clots) and activates the ability of cells and tissues to regenerate.
Athletes must be very careful about their nutrition; there are many products on the market - soy protein, protein bars, creatine, taurine, whey protein - it is worth knowing their characteristics.
To summarize, the use of the drug by athletes gives the following results:
- The elasticity of blood vessels increases.
- The level and capacity of hemoglobin is maintained.
- Insulin synthesis is normalized.
- The digestibility of carbohydrates is stimulated.
As a result, after all of the above, athletes have an increased protective function of the body.
Recent studies have not revealed any positive effect of the drug directly on muscle growth or on the athlete's strength performance, so training itself will be effective for building muscles, and the drug will help cope with heavy loads, thereby increasing their effectiveness. Important! Riboxin, like any drug, must be safe for the health of athletes, so before taking the drug, it is advisable to consult a medical specialist.
Reviews about Riboxin
Reviews about Riboxin characterize the drug from a positive point of view in their overwhelming majority. The drug has an extremely small list of possible side effects, which seems even more insignificant if we consider the entire range of indications for the use of Riboxin. The active components make it possible to effectively fight and stop the pathological effects of most common nosological entities affecting the vital circulatory system and its “main pump”.
However, the therapeutic effects of the drug are not limited to effects on the myocardium. The active ingredients promote active regeneration of the mucous membrane in case of destructive diseases of the gastrointestinal tract, and how often in the modern world do you meet a person without at least a mild form of gastritis? The positive effects also extend to the blood system, metabolic processes in the kidneys and other organs and systems.
Reviews from doctors only confirm the favorable therapeutic capabilities of the pharmaceutical drug. Of course, there are those in the medical community who postulate very dubious harmful aspects of using Riboxin, but the vast majority of qualified specialists express their “for” and universally prescribe the drug in the fight against various pathological conditions.
Reviews of this pharmaceutical drug from athletes and bodybuilders are negative. To gain weight and improve physical performance, Riboxin was used back in the 70s, after which biochemistry stepped far forward and reliably proved that the active components do not have an anabolic effect on muscle mass. Accordingly, a course of taking the drug can help only in the form of the so-called “placebo” effect. Athletes, calculating their results, notice the lack of influence and therefore scribble unpleasantly colored reviews left and right.
The situation changes in the opposite direction when it comes to the use of Riboxin during pregnancy. During a course of therapy with a pharmaceutical drug, the negative consequences of a critical condition are more easily tolerated, since the adaptive abilities of the body are significantly expanded due to the properties of the active components. The trophism of tissues and organs has also been improved, so the color and nature of the skin and the functioning of individual systems do not become a cause for concern. Based on the majority of positive reviews, we can safely say that pregnancy is much easier with Riboxin.
Effect of the drug
Action of inosine
It supports the metabolism of glucose and pyruvic acid, stimulates protein synthesis, normalizes tissue respiration, and activates metabolism during oxygen starvation and ATP deficiency.
The medicine improves blood circulation. As a result, the tissues are saturated with oxygen and receive adequate nutrition. Metabolic processes are established in them and energy supply is restored. A person feels a surge of vitality.
The drug eliminates tissue hypoxia, which is important during pregnancy, when cells experience a constant lack of oxygen. For severe injuries that cause immobilization, Riboxin is administered intravenously
Nutrients are quickly transported through the bloodstream to cells in stationary areas of the body.
The medicine will not allow platelets to stick together and form conglomerates. Prevents blood clots from forming and improves blood clotting. At the same time, blood quality increases, heart rate normalizes and stabilizes, tissue regeneration occurs (increased restoration of the mucous membranes of the gastrointestinal tract and myocardium).
The drug acts as an immunostimulant and nonspecific antiviral agent. It inhibits the development of pathogenic microorganisms. Fights measles virus, herpes, lymphoma and other pathogens of infectious diseases. Under its influence, the body intensively produces lymphocytes that kill pathological microorganisms.
Riboxin has a beneficial effect on liver function. The cells of the organ, saturated with oxygen, are actively restored. It is used in complex therapy for heart diseases. The drug is recommended for athletes and bodybuilders. It nourishes muscle tissue and promotes effective muscle building.
Riboxin price, where to buy
The pharmaceutical drug can be purchased almost everywhere at pharmacy kiosks throughout the Russian Federation. The price of Riboxin tablets is 20 rubles, and the price of Riboxin in ampoules is 80 rubles per package.
You can buy the medicine in other countries, for example, the price of Riboxin in Ukraine for the tablet form fluctuates on average about 10-11 hryvnia, and a solution for injection or infusion can be purchased for 40-50 hryvnia.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Riboxin-solopharm politvist solution for intravenous injection.
2% 5ml amp. plastic. No. 10 LLC "Grotex" 79 rub. order - Riboxin Bufus solution for intravenous administration. 2% 10ml 10 pcs. AO Renewal of PFC
103 rub. order
- Riboxin tablets p.p.o. 200 mg 50 pcs. Borisov plant
52 RUR order
- Riboxin solution for intravenous injection. 20mg/ml amp. 5ml 10 pcs. Welfarm LLC
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- Riboxin tablets p.p.o. 200 mg 50 pcs. OzonOzon LLC
77 RUR order
Pharmacy Dialogue
- Riboxin Bufus (amp. 2% 5ml No. 10)Update PFC JSC
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- Riboxin tablets 200 mg No. 50 Tyumen.khim. factory
43 RUR order
- Riboxin (tablet p/o 200 mg No. 50) BZMP
35 rub. order
- Riboxin (amp. 2% 5ml No. 10) DHF JSC
51 RUR order
- Riboxin (amp. 2% 10ml No. 10) DHF JSC
68 RUR order
Europharm* 4% discount using promo code medside11
- Riboxin tablets 200 mg n50 Tyumen HFZ
70 rub. order
- Riboxin solution for intravenous administration 2% 5 ml 10 ampBiokhimik OJSC
65 rub. order
- Riboxin avexima 200 mg 50 tablets LLC Avexima Siberia
86 rub. order
- Riboxin 200 mg 50 capsBiochemist
75 rub. order
- Riboxin Bufus solution for intravenous administration 2% 5 ml 10 amp reneval
109 rub. order
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Pharmacy24
- Riboxin No. 50 tablets PrAT "Tekhnolog", Uman, Cherkasy region, Ukraine
14 UAH. order - Riboxin 2% 10 ml N10 injection solution PAT "Galichfarm", Ukraine
34 UAH order
- Riboxin-Darnitsa 2% 5 ml No. 10 solution PrAT" Pharmaceutical company "Darnitsa", Ukraine
22 UAH order
- Riboxin 2% 20 mg/ml 5 ml N10 injection solution PAT "Galichfarm", Ukraine
25 UAH order
- Riboxin-Darnitsa 2% 10 ml No. 10 solution PrAT" Pharmaceutical company "Darnitsa", Ukraine
30 UAH order
PaniPharmacy
- Riboxin ampoule Riboxin solution d/in. 2% amp. 10ml No. 10 Ukraine, Darnitsa ChAO
37 UAH order
- Riboxin ampoule Riboxin solution d/in. 2% amp. 10ml No. 10 Ukraine, Galichfarm JSC
29 UAH order
- Riboxin tablets Riboxin tablets. p/o 0.2g No. 50 Ukraine, Tekhnolog ChAO
17 UAH order
- Riboxin tablets Riboxin tablets. p/o 0.2g No. 50 Ukraine, Darnitsa ChAO
20 UAH order
- Riboxin ampoule Riboxin solution d/in. 2% amp. 5ml No. 10 Ukraine, Darnitsa ChAO
25 UAH order
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