How to take GHRP-6 peptides correctly, what can they be combined with?

Article provided by the pharmaceutical store Anabolik Farma Date of:

2019-02-27
Views:
3,177
Rating:
5.0

Medals articles >>

Articles are loading...

Important! The “Your Trainer” website does not sell or encourage the use of anabolic steroids and other potent substances. The information is provided so that those who decide to take them do so as competently as possible and with minimal risk to health.

GHRP 2-6 - growth hormone releasing peptides, acting on the pituitary gland, stimulate the release of growth hormone (somatotropin).

GHRP-2 - growth hormone stimulator[edit | edit code]

GHRP-2 Key application points GHRP-2
GHRP-2

(from the English.
Growth Hormone Releasing Peptide - 2
- peptide that releases growth hormone) or
Pralmorelin
- a stimulator of growth hormone (somatotropin), which has shown high effectiveness in people when administered sublingually and buccally. GHRP-2 is perhaps the only and most powerful booster (stimulator) of somatotropin production that currently exists. GHRP-2 is an oligopeptide that is able to penetrate through the vessels of the oral cavity and enter the bloodstream bypassing the liver. Studies have shown that GHRP-2 stimulates the pituitary gland, which leads to an increase in somatotropin secretion by 7-15 times (other growth hormone stimulants based on GABA and amino acids increase the level by no more than 2-3 times from the original).

Growth Hormone Releasing Peptide - 2 consists of six amino acids connected in series. This growth hormone stimulator is part of a group of peptides that interact with G protein-coupled receptors of the pituitary gland and hypothalamus; it also activates ghrelin receptors, which in turn leads to increased appetite.[1][2] These peptides were first obtained at the end of the last century from methenkephalin (an artificial peptide). Although GHRP-2 has no structural similarities to growth hormone-releasing hormone (an endogenous bioactive substance that naturally stimulates growth hormone production), it has demonstrated similar effects on the pituitary gland in clinical trials.

The growth hormone stimulator GHRP-2 has a low molecular weight, so it easily penetrates the well-vascularized oral mucosa, which avoids the parenteral route of administration. The effectiveness and good tolerability of the sublingual, intranasal and buccal administration of the drug is confirmed by medical studies.[3]

Clinical trial results published in the Journal of Endocrinology and Metabolism in 1997 showed that Growth Hormone Releasing Peptide - 2 increased growth hormone production in both children and adults, and even in the elderly.

Main effects[edit | edit code]

• Growth hormone secretion stimulator
• Increased appetite (due to activation of ghrelin receptors)[4]
• Reducing fat mass and increasing muscle mass (that is, increasing definition) [5]
• Reducing cholesterol levels
• Strengthening Bones
• Improving skin properties (rejuvenation effect)
• Protective effect on the liver
• Anti-inflammatory effect

GHRPeptide-2 is the most powerful and at the same time safe stimulator of somatotropin secretion of all those currently existing on the sports nutrition market (its potency can be compared with growth hormone preparations), which is confirmed by a number of independent studies, a key list of which is presented here.

Doses and regimen[edit | edit code]

The level of somatotropin depending on the dose of GHRP-2 when administered intranasally.
Studies have determined that the growth hormone stimulator GHRP-2 has a dose-dependent effect, that is, the increase in the level of somatotropin directly depends on the dose of this substance taken, and regardless of gender, age and amount fat mass.[6] Later, another study was conducted on children [7] where the dependence of the concentration of growth hormone on the dose of GHRP-2 was clearly determined (see graphs).

To obtain an effect in bodybuilding, GHRP-2 is used in a dose of 1-2 mcg

per 1 kg of body weight, 2-3 times a day.
That is, the average single dose of the drug in bodybuilding varies between 100-200 mcg
. Most often, 2-3 injections are performed every day (15 minutes before meals, after training and before bed), 100-200 mcg intramuscularly.[8][9][10][11] There are reports of the use of the substance at a dose of 1000 mcg 2-3 times a day, without the development of adverse reactions.[12] However, we do not recommend increasing the dose, since the rate of increase in the effect of the peptide is significantly reduced at doses above 200 mcg, and at the same time the concentration of cortisol and prolactin may increase. Yuri Bombela recommends using Cabergoline (Dostinex) to reduce prolactin.[13]

It is advisable to combine this peptide with GRF(1-29) or CJC-1295 to achieve maximum (synergistic) effect, save money and solve the problem of desensitization.[14]. Combined courses are described in the relevant articles.

Presumably due to the short half-life of GHRP-2, there is no significant increase in blood IGF-1 concentrations despite a high but transient increase in growth hormone.[15][16] Therefore, it is recommended to combine this drug with other peptides with a long half-life (CJC-1295)

Preparation and storage of the solution

[17]

You should cool the bottle to room temperature, then add the required volume of water for injection (which should flow down the wall of the bottle) and stir with smooth rotating movements (do not shake) or let it stand in the refrigerator. The solution is quite stable. Moreover, stability in this case does not depend on the type of solvent (bacteriostatic water or water for injection). Shelf life in the refrigerator is approximately 30-35 days.

Main effects:

• Stimulator of growth hormone secretion;
• Increased appetite (due to activation of ghrelin receptors);
• Reducing fat mass and increasing muscle mass (that is, increasing definition);
• Reducing cholesterol levels;
• Strengthening bones;
• Improving skin properties (rejuvenation effect);
• Protective effect on the liver;
• Anti-inflammatory effect.

GHRPeptide-2 is the most powerful and at the same time safe stimulator of somatotropin secretion of all those currently existing on the sports nutrition market (its potency can be compared with growth hormone preparations), which is confirmed by a number of independent studies.

Sports nutrition[edit | edit code]

Synergistic effect of GHRP-2 and arginine (maximum concentration)
Growth hormone stimulants based on GHRP-2:

• Hexaghen by MuscleMeds
• Hemotropin from Nutrabolics
• Hemogex from VPX
• Xomatropin from ASN

So far, only these brands are on the market, and not a single manufacturer indicates the dose of GHRP-2, although this is the main component of the supplements. This circumstance may suggest that they use very low dosages that are not capable of producing the desired effect.

There is also a drug called Xentropin

, in which the proportion of the active substance is also unknown.

Combination[edit | edit code]

It is recommended to combine GHRP-2 supplements with other growth hormone stimulants - arginine, GABA and glutamine, this allows for a synergistic effect and increases growth hormone levels to a much greater extent.[18] The combination of these supplements is safe for health.

What is it used for and side effects?

Since the drug does not have a strong effect on strength indicators, it has not found wide use in powerlifting and weightlifting. The effect of the GHRP 6 course is most valued in bodybuilding.

Unlike many analogues, the substance is rarely used as a means of losing weight due to its appetite-enhancing properties. It is more advisable to use GHRP 6 while working to build high-quality muscle mass.

Side effects

The absence of side effects is one of the key advantages of the drug. No serious side effects were identified either during clinical studies or during widespread use, as evidenced by positive reviews on the Internet.

People who used GHRP 6 noted only a significant increase in appetite in the first 2 weeks after starting the course and a slight burning sensation on the skin at the injection sites (a normal reaction of the body to frequent injections).

At very high dosages (from 650 mcg per day), high levels of cortisol and prolactin were observed. But if you follow the recommendations and adhere to standard dosages, the risk of this side effect will be minimal.

Notes[edit | edit code]

1. Blandine Laferrere, Cynthia Abraham, Colleen D. Russell. Growth Hormone Releasing Peptide -2 (GHRP-2), like ghrelin, increases food intake in healthy men. J Clin Endocrinol Metab. February 2005; 90(2): 611–614.
2. Argente J, Garcia-Segura LM, Pozo J & Chowen JA. Growth hormone-releasing peptides: clinical and basic aspects. Hormone Research 1996 46 155–159.
3. Department of Pediatrics at the University of Arkansas for Medical Sciences, published in the Journal of Endocrinology and Metabolism in 1995, “All 15 children had a significant GH response to 15 pg/kg dose.
4. Blandine Laferrère, Cynthia Abraham, Colleen D. Russell and Cyril Y. Bowers – Growth Hormone Releasing Peptide-2 (GHRP-2), Like Ghrelin, Increases Food Intake in Healthy Men – Obesity Research Center (BL, CA, CDR), St . Luke's Roosevelt Hospital Center and Columbia University College of Physicians and Surgeons, 1090 Amsterdam Avenue, New York, New York 10025; and Tulane University Health Sciences Center (CYB), New Orleans, Louisiana 70112
5. Gonadal status and body mass index jointly determine growth hormone (GH)-releasing hormone/GH-releasing peptide synergy in healthy men. J Clin Endocrinol Metab. 2008 Mar;93(3):944-50. Epub 2007 Dec 11
6. Pralmorelin: GHRP 2, GPA 748, growth hormone-releasing peptide 2, KP-102 D, KP-102 LN, KP-102D, KP-102LN. Drugs in R&D 2004 5 236–239
7. C Pihoker, R Middleton, GA Reynolds, CY Bowers and TM Badger — Diagnostic studies with intravenous and intranasal growth hormone-releasing peptide-2 in children of short stature — Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, USA ( 2006)
8. https://www.ironmagazineforums.com/research-chemicals/158586-ghrp-2-dosing.html
9. https://www.uk-muscle.co.uk/muscle-research-peptides/101507-ghrp-2-what-dose.html
10. https://buypeptides.org/ghrp-ipamorelin/dosage-instructions.html
11. https://bodypeptides.com/ghrp-2.php
12. https://www.professionalmuscle.com/forums/peptides-growth-factors/88141-boom-dosing-ghrp-2-a.html
13. https://anabolicstore.com.ua/index.php/articles/pharmacology/medicines/item/331-peptides-other-side
14. "Inhibition of growth hormone release after the combined administration of GHRH and GHRP-6 in patients with Cushing's syndrome"
15. https://joe.endocrinology-journals.org/content/155/1/79.full.pdf
16. https://jcem.endojournals.org/content/91/12/4792.full
17. Recommendations from Yuri Bombela
18. Synergy of L-arginine and GHRP-2 stimulation of growth hormone in men and women: modulation by exercise - Am J Physiol Regulatory Integrative Comp Physiol 279:1467-1477, 2000.

How to use GHRP-6?

GHRP-6 is a water-based injectable solution that you will need to mix with sterile water. Remember that it is important to store GHRP-6 in the refrigerator after mixing. It is usually recommended to use it within 3-4 weeks, so do not leave the diluted drug for a longer period, even in the cold.

After thorough mixing, the drug is usually administered subcutaneously

using a syringe. For best results, it must be taken daily. Athletes usually take several injections per day for better absorption. An interesting fact is that GHRP-6 works best when blood sugar levels are low. Also, you should not eat anything for an hour after using it.

If GHRP-6 is used solo, the recommended dose ranges from 100 to 400 mcg per injection, and if combined with another GH, doses can be cut in half.