Getting rid of excess fat is a hot topic in all the world's sports resources. Those who want to quickly lose weight are offered sets of exercises, special diets and fat burners, which, according to experts, help solve the problem. The focus of this article is one of the best fat eliminaters present on the world market - Methyldrene 25. Reviews of it can most often be found in the media. This article will focus specifically on this weight loss product.
Market positioning
The drug is sold only in specialized sports nutrition stores. The manufacturer positions it as a means for burning fat, but there are often cases when the seller offers it as a complex that should be drunk before training to stimulate the nervous system. As a result, the fat burner Methyldrene 25 has reviews in two categories: as a weight loss product and as a training stimulant.
There is something to think about for many beginners who want to purchase a universal product. Although the manufacturer limited the use of the drug to persons under 18 years of age and pregnant women, he did not reveal all the secrets to the buyer, so as not to lose the market.
Compound
Fat burner Methyldren is based on an active combination of components:
- synergetic complex ESA;
- herbal central nervous system stimulants;
- metabolism activators;
- hunger suppressants;
- complex of vitamins, microelements;
- thermogenics, lipolytics.
A unique combination of natural ingredients programs the body to burn fat, converting it into useful energy. The place of the lipid tissue layer will be taken by structural muscle tissue.
Effective Ingredients
Reviews about the drug Cloma Pharma Methyldrene 25 primarily concern the ECA mixture, which stands for: ephedrine, caffeine and aspirin.
- Ephedrine. It has a psychostimulating effect, improves concentration and dilates blood vessels. He is also credited with an increase in blood pressure, however, according to doctors, this phenomenon is caused by stimulation of the nervous system.
- Caffeine. Enhances cardiac activity and adrenaline production.
- Aspirin. Oddly enough, it has two tasks: it enhances the effect of ephedrine and caffeine, while lowering body temperature by affecting the hypothalamus.
As a result, this explosive mixture is very popular among fat burner manufacturers. After all, Cloma Pharma is not the only manufacturer of similar drugs on the market.
Composition of fat burning tablets Methyldrene 25 Cloma Pharma
The components that make up the fat burner work in synergy. This means that they enhance each other's actions. Thanks to this, the user gets much better results than if he took them alternately in the form of single-component drugs.
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The composition of "Methyldren 25" includes:
- ECA mixture (ephedrine + caffeine + aspirin). The bunch is very popular in bodybuilding and fitness circles. It is taken if you want to lose weight and improve muscle definition, and set new records. Ephedra triggers thermogenesis and ensures the conversion of unnecessary fat cells into energy, increases heart rate and increases training performance. Has diuretic properties. Caffeine supports fat burning processes and increases performance. Enhances the effects of ephedra extract. Goes well with caffeine. Aspirin improves blood circulation, stimulates the delivery of nutrients and oxygen to muscle tissue, and relieves inflammation and pain.
- Vitamin B6. It is important for the synthesis of hemoglobin, serotonin and aminobutyric acid, improves the functioning of the nervous system, and prevents the occurrence of seizures (which is especially important during the recovery period after exhausting sports training).
- Vitamin B12. Accelerates weight loss. Takes part in the processes of hematopoiesis and the formation of bone tissue. The compound is indicated for stress, nervous feelings, and arterial hypertension. Has a beneficial effect on the immune system.
- Chromium picolinate. Increases the athlete's body's resistance to physical activity, promotes rapid muscle mass growth, and slightly dulls the feeling of hunger. In general, vitamins B6 and B12, together with chromium picolinate, guarantee the normal course of metabolic processes.
- Citrus aurantium (aka synephrine or bitter orange). A Chinese fruit that has been used to treat obesity since ancient times. The component is often added to fitness supplements and sports nutrition. It suppresses appetite, stimulates fat burning, and accelerates metabolic reactions.
- Ginseng. It does not belong to the category of fat-burning substances, but is still part of Methyldrene 25. The manufacturer used it as a stimulant of the immune system, an excellent sedative in stressful situations. It is known that ginseng has a good effect on the functioning of the gastrointestinal tract, the condition of the skin, and accelerates the elimination of toxic compounds. Taking ginseng is recommended for recovery after training.
- Ginger root. Reduces weight, restores healthy digestion, fights high blood pressure. It makes the effect of the ECA complex more pronounced.
- Hoodia cactus extract. It is obtained from a prickly plant native to Africa and Namibia. There, the local population uses raw materials to reduce hunger and get rid of thirst. The component is very powerful - for some people it completely removes the desire to eat. The extract acts on the body in the following way: it stimulates the hypothalamus and instills a feeling of satiety in the brain.
- Cayenne. Cayenne pepper suppresses appetite and speeds up metabolism. Normalizes blood circulation and increases sexual desire in men. It has a pronounced anti-inflammatory property and cleanses the blood. The component supports thermogenesis and accelerates metabolic reactions.
- Phenylethylamine hydrochloride. Stimulant, potency enhancer. It helps you focus and provides intense training in any conditions. It lifts your mood, which has a positive effect on your well-being and training results.
- Green tea. Source of polyphenols. Reduces blood sugar levels, improves metabolic processes, and has an antioxidant effect. The extract obtained from green tea stimulates the breakdown of fat cells, creating favorable conditions for effective weight loss.
- Theobromine. Cocoa alkaloid. Dilates blood vessels, accelerates the removal of excess fluid, improves blood supply to internal organs and muscle tissue. It's very invigorating. Facilitates training during periods of high mental and physical stress.
- Yohimbine hydrochloride. A natural aphrodisiac extracted from the yohimbe plant. Facilitates fat burning and makes body drying as effective as possible. By converting fat deposits into energy, it significantly increases endurance levels. Yohimbine improves focus, memory, thinking, and attention characteristics.
- 5-hydroxytryptophan. A substance that normalizes sleep and reduces stress levels. It improves mood and helps cope with strong anxiety. What is important is that it reduces sensitivity to pain.
- Methylsynephrine. A relative of ephedrine. Leads to the destruction of fat deposits, converting fat cells into a source of energy. Increases heat production. Methylsynephrine reduces appetite and provides mental focus.
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Methyldrene 25 Cloma Pharma is the optimal choice for both men and women. Despite its rather impressive composition, it has a gentle effect on the human body and rarely causes serious side effects.
What does the law think about this?
All over the world, ephedrine is banned by legislative bodies (except in some countries in South America, Asia and Africa). After all, in fact, it is a real psychotropic drug. The manufacturer was helped to circumvent the law by simply deceiving customers. The ephedrine declared in the composition was replaced by a synthetic product called “Ephedran”. Yes, it has similar symptoms, but its effect on the nervous system is so insignificant that even with an overdose, a person will not be able to feel the excitement that is achieved under the influence of ephedrine.
What about the composition of Methyldrene 25? Reviews in the media claim that the fat burner copes with the task. This is a proprietary mixture containing yohimbine, raspberry extract, white willow bark and other plant extracts that affect the human nervous system. They are not prohibited by the state and are sold without a prescription in pharmacies (you just need to know the proportions).
Body tolerance
The manufacturer is also silent about the human body’s reaction to the drug. After all, everyone’s perception of the components in a mixture is different. Only reviews of Methyldrene 25 will help here (the instructions are powerless here). Naturally, the “advantages” section is filled in by athletes whose nervous system responded positively to ECA, while negativity is poured out by people whose body does not respond to the drug. By the way, the latter are not offended by their health, because their body eliminates the drug in the stomach, not allowing the “chemistry” to affect the nervous system.
Therefore, before purchasing an expensive fat burner, you need to find out the body’s tolerance to the drug (take a sample). Serious sellers in the sports nutrition market provide this opportunity. It is recommended to check according to the “+1” scheme: on the first day, 1 capsule, on the second – 2, on the third – three capsules during the day. If there is no reaction, the drug is not suitable for you, otherwise after the first dose it will become clear that the fat burner is working.
Analogs
If Methyldrene is not suitable, then you should look at drugs with a similar effect:
- Nutrex Lipo-6X is a powerful supplement aimed at breaking down fat through the synthesis of tyrosine.
- Ge Pharma Pyro Burn - similar to Methyldrene 25 in terms of ephedra content.
- Thermonex BSN - its active ingredients are caffeine and green tea, so it is good for athletes who do not perceive ephedra well.
Methyldrene 25 is a very effective drug that is trusted for a reason. Its properties allow you to spend more time in the gym, which means improving your results and achieving your goals in sports.
About the reception itself
How many people - so many opinions. The information in the instructions for use is so superficial that even the sellers of Methyldrene 25 do not recommend trusting it. Reviews in the media recommend taking one capsule during the first three days with breakfast. Yes, with food, many active substances are eliminated even before entering the blood. But if the body is too sensitive to one of the components, such use will reduce the response to the drug in the central nervous system or cardiovascular system.
In the following days (if everything is in order), you can take 2-3 capsules per day. In the instructions, the manufacturer indicated that taking the fat burner 6 hours before bedtime is undesirable. Here he is 100% right. After all, with an excited nervous system, it’s unlikely that anyone will be able to fall asleep.
Instructions and indications for use
Methyldrene 25 is intended to inhibit the formation of fatty conglomerates in men and women. Athletes of those sports that require high speed reaction, physical strength, and performance use this sports supplement to increase performance.
Bodybuilders use Methyldrene to structure muscle fibers and grow muscles. The initial dose is one capsule. If there are no adverse reactions, the dosage is increased. The optimal number of pills is three. Take Methyldrene 25 ephedra 40 minutes after morning and evening meals. During the period of use, you need to increase the daily liquid volume to 2 liters.
About the sensations when taking it
Each person describes the symptoms after taking a fat burner differently, sometimes attributing miraculous properties to the drug Methyldrene 25. It is generally better not to read reviews from girls.
- Increase in body temperature. Yes, it rises by 0.5-2 degrees. This is quite normal for a healthy body. This symptom is a side effect when caffeine enters the body. During sleep, body temperature normalizes.
- Cardiopalmus. Side effects of the same caffeine and ephedrane. An increased heart rate causes fat to be burned, so this effect is key when losing weight. If the buyer has problems with the cardiovascular system, the drug is contraindicated.
- Changes in mood. Within one day, nervous excitement changes to complete detachment from the outside world hundreds of times - this is the body’s usual reaction to a psychotropic drug.
- Feeling of hunger and nausea. To burn fat you need water. These two are symptoms of dehydration, so you need to drink a lot of water.
Additional sports nutrition for better results
You must understand that any diet, especially one supported by a fat burner, has not only a positive effect on the body, but also, in some way, a negative one. But this does not mean that some terrible side effects await you) This means that you need to approach the fat burning process wisely, choosing a balanced diet, competent exercise and additional support in the form of sports nutrition.
And first of all, if you don’t want to burn your muscles, you need BCAA, well, or a complex of amino acids. Our muscles need them every day, even during the period when you do not limit yourself in nutrition, what can we say about a strict diet and rapid weight loss? Any burn is primarily stress for our muscles, so don’t forget to support them!
Naturally, the second thing that loads Methyldren as a strong stimulant is our central nervous system. No matter how much we would like to constantly get all the buzz from stimulants, sooner or later this will stop, as addiction will appear, and your nervous system will simply be overloaded. This is fraught not only with insensitivity to stimulants, but also with weakness of your central nervous system, constant fatigue and lethargy. So, to maintain brain function and quality rest, we can advise you to try nootropics and relaxants. By the way, the latter also stimulate the production of growth hormone, which helps you recover and not lose your precious muscles (or even better, increase the production of testosterone with a test booster, and then your muscles will not be afraid of any catabolism at all)).
Well, and, of course, don’t forget about vitamins and minerals. This is generally a basic supplement always and in any case. Without them there will be neither a beautiful body nor good health!
Conclusion about Methyldren: fat burners are quite tough, give a quick effect, are excellent as a pre-workout and energy drink for lethargy and bad mood. Ideal for lovers of hard LJ!
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Discussion: 32 comments
- Vanya says:
Normal burners, but you need to be careful with them! Overall it works quite well. After the first dose I felt a lot of energy, the difference is especially noticeable during cardio. I noticed one small side effect - my eyes were red, but my general condition was normal. Strength indicators have noticeably improved and endurance has finally appeared. - MarinkaMalinka says:
I liked Elite better. She endured it more gently. I don’t want to break into yellow once again. The hand reaches out more to the Elite.
- Andrey says:
I only take this supplement in the morning, because at this time I can’t eat well, and the drug dulls the feeling of hunger. I don’t drink in the evening, because the energy it gives is enough for the whole day. A good thing!
- Max says:
I'll start with the side effects: I've heard many people write about headaches and rapid heartbeat. Indeed, even after training, the heart does not calm down immediately. Therefore, those who have problems with this vital organ are categorically not recommended to use the drug. I myself suffered from headaches several times during my appointment. All this is easily knocked down by glycine. Everything, as they say, is individual, but I can say that this fat burner is still good and effective.
- elena586 says:
Well, I’ll add my 5 cents to all the reviews. I began to lose weight very quickly, because during training I felt a surge of strength and energy. The classes themselves became much more intense, endurance and strength increased. As soon as I started taking the drug, my daily routine was a little lost (I didn’t want to sleep, I didn’t get enough sleep). At first, the rapid heartbeat was a little alarming, but then I got used to it. I'm not afraid of this because I don't have heart problems. It is better to take a lot of liquid with you to training, because during exercises you can squeeze out the T-shirt on yourself - so much water is released from the body.
- Grileta says:
I took a course of Methyldren Elite. I can say that the fat burner is very effective (I had more than enough energy during the workout). However, sometimes I felt a headache. Despite this, I think the product is good.
- Dimas says:
Yes, I also saw a lot of positive reviews about Methyldren, but the first impression was not very good. After the first dose there were unpleasant sensations - bitterness, but then everything went away. The body has gotten used to it and now everything is fine. I have gained strength and mood, and I no longer feel drowsy at work.
- Alexey Iv... says:
The result is quite good - 7 kg per month. I did not take it every day, but only on training days: before visiting the gym and before anaerobic training. I usually took two of them, but there was a small side effect - my head hurt a little. I didn’t feel like eating at all, but despite this, my strength and endurance increased significantly! Now I devoted more time to cardio, because my body simply craved hardcore work. I had to drink a lot of water, up to 3 liters a day. Due to a mild but not very pleasant side effect (headache and insomnia), I started taking one capsule at a time. At the same time, the effect of the drug remained at the same level, which is encouraging. For better results, I recommend following a diet (generally giving up sugar and fast carbohydrates). There is no need to stuff yourself with buns, fried foods and other unhealthy foods. In combination with this fat burner, the diet will bring much greater effect. Do not drink coffee or other energy drinks under any circumstances. And, of course, without training, this supplement will not work. In the gym, it’s better to work intensely until you fall off your feet, otherwise you won’t be able to sleep later. Another tangible benefit for me is a surge of strength and a good mood even in stressful situations both at work and at home.
- Ilya says:
I agree 100%!
- Elena says:
I started drinking yesterday, I was pleased with the results, the training went with a bang, I did exactly 2 times more than usual, but then it took a long time to let go, I wasn’t myself all evening. I didn’t have a headache, like many people here, but my heart felt somehow uncomfortable and there was some kind of bitterness in my mouth, I couldn’t sleep for a very long time
- Oleg says:
Something doesn't feel right to me. I’ve been drinking for the second day, but there’s no surge of strength as they say! Fatigue, lethargy and severe sweating. I have no strength to work out at all. And I took it before, but other LJs and everything was fine! It’s probably better to quit, otherwise you never know... I won’t wake up tomorrow!
- Larisa says:
Everyone is doing well, but my body is unique, the 1st week I had palpitations, after that my body got used to it, I took the whole course of 3 pcs/day, additionally 3g of carnitine before training, strength training 4 times a week + 1 day cardio, I sleep like a woodchuck, my appetite didn’t disappear anywhere, I don’t feel a special surge of energy, at the end of the month I was minus 0.5 kg, I expected more
- Natusya says:
I can’t sleep, I want to walk, walk, walk!!!
- Ira says:
Elite is not a bad thing, but for me personally one capsule in the morning was not enough - there was no effect! If I hadn’t bought it from a serious sports nutrition store, I would have thought that I had stumbled upon a fake! And vice versa: the appetite appeared wild! Before the elite took shred matrix - the result was many times better! I already wanted to get rid of the elite, as they suggested to increase the dose: 2 capsules in the morning. This is where the effect began! And thermogenic, and the appetite is gone! I understand that there is a load on the central nervous system, in a week I will reduce the dose again. Yes! I lost 8 kg in 3 weeks!
- Vika says:
It’s very strange to see bad reviews about Methyldren 25... when I bought it for the first time, I couldn’t find any reviews at all, so I had an unbiased first impression. the burner is very good. yes, it is quite aggressive, but this does not make the product bad! you just need to choose the dosage for yourself and drink it correctly, without forcing yourself with a diet of 500 kcal per day or, in the opposite case, gorging yourself like a bear before hibernation. I took it at first, 1 piece a day, then I got used to it and introduced another capsule. I felt unusual, but good. I adjusted my diet a little, introduced more cardio, and took extra vitamins. and I didn’t notice any side effects! I only drink it in courses for no longer than 1.5 months. on the scales it is usually -3-5 kg. For me this is the optimal result!
- GermaN says:
Hmmm. Reviews from women about Methyldren 25 are usually amazing. “I’m not losing weight,” “I feel sick,” “I feel bad.” Usually such people have no idea what fat burning is and how to do it correctly, they buy fat and hope that after the course they will gain the body of a fitness model. infuriating! Methyldren is a cool drug, but complicated. Not suitable for everyone. And if you drink it crazy, you will only get disappointed and write another incompetent, angry review. Guys, girls and boys, just learn to use sports drink correctly, and there will be no problems!
- Triumph says:
I didn’t think that reviews of the fat burner Methyldren were so different. it’s strange because I only heard good things from my trainer and friends at the gym. Maybe everyone's body is different. I noticed only one minus for myself, and that was related to my mistake. When I took it in the morning on an empty stomach I felt slightly nauseous. The problem was solved by taking it after breakfast. Otherwise, it's a decent piece!
- luisamarkisa says:
I liked the fat ones. I took one capsule before training, and on rest days, 1 in the morning. I didn’t put much strain on my body, but I got good results. volumes decreased over the month. I'm thinking of repeating the course.
- Clara says:
I bought it a long time ago, started drinking it recently, and now I’m afraid! Taking one tablet on an empty stomach in the morning, I thought my heart would stop. I couldn't sit still. All day like an electric broom. There were no side effects, but inside I felt like I was having a panic attack. I couldn’t sleep 15 hours after taking it, I had to do breathing exercises to calm my heart. Taking glycine didn't help at all. So now I’m wondering whether it’s worth continuing to take it?!
- Maryana pro says:
It’s clear that reviews of Methyldrene 25 are always different everywhere. many things are individual, but one thing always remains - if you are under-recovered, but your body will take the fat burner BAD! because this is also stressful for him. The fat burner should be consumed by completely healthy, physically fit people. I definitely take vitamins, minerals and healthy fats along with Methyldren 25 elite and everything is great!
- fugitive says:
I saw some reviews from women about Methyldern 25 that the body becomes flabby after losing weight. maybe you shouldn't drink this crap???
- max says:
runaway, Methyldrene Elite has nothing to do with this!!! flabby body because the muscles are not developed. Ladies lose weight, don’t exercise and hope that underneath the fat there will be juicy curves. but to hell with it!
- dashunia says:
Yes, I agree. I myself got problems after the first fat burner (it was not methyldren). I didn’t play sports, I just decided to buy it and thought I’d lose weight. I lost about 2 kg, but I felt disgusting, nauseous, and had a headache. A couple of years later, when I became interested in fitness and decided to try Cloma Pharma fat burners. I already drank correctly and with another sports drink, during the course I dried out well and felt as usual. so fat burners also need to be taken correctly.
- Alexey says:
I once tried yellow and everything was fine. fat is like fat.
- Dobrynya says:
I was more impressed by Elite who. It gives me more energy and a more impressive result. ECA fat burners are my favorite!
- farina says:
I'm delighted with methyldrene! This is my favorite fat so far! and suppresses appetite and energy for a day! Even with a small cut in calories it works!
- Alexandra says:
Tell me, did anyone gain twice as much while stopping the drug? My husband scares me with this, that’s why I’m afraid to start (the methyldren has been in the car for weeks now, it’s boring(
- Lisa says:
Alexandra, no, you won’t dial
- Lisa says:
If you think that drinking LiveJournal will give you a great figure, you are mistaken. If you plan your diet wisely and use sports nutrition wisely, you will be pleased with the results. In addition to LJ, you should add protein and vitamins. Only those who don’t know any sense write that they take LJ in the morning, and 2 capsules each, they don’t lose weight, don’t sleep at night, that their body becomes flabby, etc.
- Svetlana says:
Good afternoon. I started drinking 1 capsule in the morning after breakfast. I drank for a week. Yesterday I added a second capsule to lunch, by the evening my whole body was covered with polka dots ((((At the same time I take the vitamins Optivumen, Lcarnitine and VSAa. What should I do? stop taking it? Who knows about the compatibility of the drug?
- Ekaterina 666 says:
Good afternoon, I’ve read almost all your reviews, I’m generally not a fan of writing myself, I like to read more) I’m working out with a trainer, and I have a problem before the competition in May of this year to lose the remaining fat, my trainer advised me to use Methyldren, I’m doing it two hours in the gym, an hour of iron and an hour of cardio. Methyldren really gives me crazy energy, and in addition to this, I also drink pharmaceuticals. There are no headaches, only when I take a pill in the morning for a couple of minutes it feels like heartburn, but this can be explained by the fact that it contains ginger root. My heart reacts very well, because in addition to these miracle pills, I drink 6 more cups of coffee, two spoons in each. Training takes place on a 2/2 schedule due to work. And so, as for the result, I can say at the moment, since I just started, the result is externally and in centimeters, but not on the scales (although weight does not play a role, but only the quality of the structure and formation of the body) I also want to say, or rather agree with you on By drinking more water, during training there really is increased sweating, which is also a plus. This is an excellent drug for me because no matter what I have tried, this is the only thing that doesn’t give me headaches. Very pleased.
- Vitaly says:
A good fat burner. The temperature is 37.7, but it doesn’t cause discomfort. 4 workouts in the gym and 3 cardio - fat burns!
Side effects
Many potential buyers are stopped by reviews about the drug Methyldrene 25: side effects, violation of the law, and some other negative things about the fat burner. All this is complete nonsense, written by people who have never taken sports nutrition (by the way, they are the ones who consider protein a “chemical”). If you turn on your brain and think logically, it will become clear that not a single state in the world will allow such a drug to be on the market.
Yes, there are symptoms: dizziness, nausea, increased heart rate, and the like. However, they are the ones who force the body to spend fat reserves - to eliminate the consequences caused by chemical reactions in the body at the expense of energy (ATP). The abnormal state of the nervous and cardiovascular systems is a small price to pay for eliminating fat.
Side effects of Methyldrene 25 Cloma Pharma
Not everyone tolerates the fat burner Methyldren 25 equally well. Some people who started taking it were forced to stop using the drug due to:
- A sharp increase in heart rate;
- Rapid heartbeat;
- Pain in the heart area;
- Discomfortable sensations in the abdomen;
- Nausea, vomiting, intestinal upset;
- Problems with the functioning of the thyroid gland;
- Headaches;
- Trembling (tremors) of the limbs.
Typically, these side effects when using Methyldren 25 occur if a person has exceeded the dosage recommended by the manufacturer, has been taking the composition for too long, or has acute or chronic diseases.
About doping
There is another wonderful drug on the world market called Methyldrene 25 Elite. Reviews about it are quite interesting. It is credited with the function of a complex that is used before training to improve the physical endurance of the body. The fact is that the manufacturer added a doping called “1,3-demityl-aminolamine”, popularly called “geranium”, to the ECA mixture. But this additive is also banned by the Ministry of Health in all countries. Accordingly, the drug contains a synthetic substitute.
But replacing the doping with a weaker component did not particularly affect the effectiveness. Therefore, the buyer does not lose anything when purchasing this wonderful fat burner. Mental concentration, increased heart rate, increased temperature and sweating - a set of necessary properties that ensure rapid fat burning will appeal to every athlete.
Recommendations from professionals
Few athletes pay attention directly to the process of burning fat. We are talking about metabolism, when the body takes a fatty acid molecule from the fat depot and delivers it to the cell with mitochondria for subsequent ATP synthesis. According to biological processes, the transport role is performed by an amino acid called L-carnitine, produced by the liver. Its reserves in the body are insignificant, therefore, it is not possible to burn all fatty acids in the cells.
Therefore, professionals recommend consuming 2-4 grams of the amino acid L-carnitine per day in addition to the fat burner. It is worth noting that there are many studies proving the harmlessness of this supplement. As reviews confirm from the combined use of the amino acid and the drug Methyldrene 25, there are absolutely no side effects. There is nothing strange in this - a normal physiological process of synthesis of a complex substance.