Oxandrolone: ​​dosages, properties and side effects

Oxandrolone is an anabolic steroid with a low level of androgenic activity and a high anabolic index, now actively used in bodybuilding and beyond. It is also used by boxers, skiers, powerlifters and track and field athletes. It was originally created in the USA back in 1964, and was used in secular medicine for the supportive treatment of HIV-infected patients, as well as for osteochondrosis, anemia, diabetes, osteoporosis, for tissue restoration after burns, for strengthening bone tissue, etc. Currently known under such brand names as Anavar (original name), Vasorome, Bonavar, Oxandrolin, Oxandrin, Anatrophyll, Oxandrolone.

What is Oxandrolone

The steroid drug Oxandrolone was synthesized by the American pharmacological company Searle Laboratories in the middle of the last century. The product is a 17α-methylated heterocycle of dihydrotestosterone (DHT), with an oxygen atom instead of a carbon atom. It has gained wide popularity due to its high anabolic activity - acceleration of protein synthesis, which also affects the regeneration and formation of cells of tissues, organs and muscles. Produced under the trade names:

• Anavar;
• Vasorome;
• Oxandrine;
• Oxandrolin;
• Oxanoger.

Combi course

For the most part, it is intended only for men, since oxandrolone is used together with other AAS (anabolic androgenic steroids). This is where the name of the course comes from, which means combined. In a solo course, only oxandrolone is used and no other drugs at the same time. Here the dosage of the main drug is higher.

To achieve athletic results, men take the drug Oxandrolone

Oxandrolone + AAS (Sustanon or Primobolan):

• first week – 40 mg per day + AAS daily norm;
• second week – 40 mg per day + AAS daily norm;
• third week – 40 mg per day + AAS daily norm;
• fourth week – 40 mg per day + AAS daily norm;
• fifth week – 40 mg per day + AAS daily norm;
• sixth week – 40 mg per day + AAS daily norm;
• seventh week – 40 mg per day + AAS daily norm;
• eighth week – 40 mg per day + AAS daily norm;

Sustanon is administered intramuscularly, one milliliter once a day.

Primobolan, unlike the previous drug, can be taken orally in doses of 50-100 mg. per day or 300-400 mg intramuscularly.

Biological effect

Among other drugs in the steroid group, Anavar stands out due to its low androgynous effect. Its active component does not have the ability to aromatize - it is not converted into estrogens; liver toxicity is moderate, anabolic activity is 400% of testosterone. At daily doses of less than 20 mg, it does not affect the secretion of this hormone, without inhibiting the hypothalamic-pituitary-testicular axis; after a three-month course, it suppresses its production by 67-70%.

During clinical trials in patients with burns of more than 40% of the body surface area, an improvement in tissue composition and acceleration of their regeneration was recorded when taking the drug. The medicine was originally intended for:

• treatment of disorders accompanied by loss of muscle mass;
• complex HIV/AIDS therapy;
• treatment of osteoporosis.

Due to the high popularity among bodybuilders and the spread of cases of abuse in the sports environment, all dosage forms of the drug, its salts, isomers, and esters were classified in the United States as controlled substances and are considered doping. The medicine is classified as an orphan drug (drugs used to treat rare diseases) and is highly effective in treating:

• alcoholic hepatitis;
• progressive muscular dystrophy;
• disorders of protein metabolism due to injuries, burns, radiation therapy;
• Turner syndrome;
• weight loss in HIV-infected patients;
• hereditary angioedema;
• anemia;
• protein catabolism after long-term corticosteroid therapy;
• osteochondrosis;
• osteoporosis.

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Oxandrolone for fat burning

The main therapeutic effect of the drug is to increase the relief and hardness of the muscles. Gaining muscle mass and burning fat are considered secondary effects. A study of the fat burning effect of taking the drug was conducted by the manufacturer of Anavar, and included men over 60 years of age who did not engage in strength training.

With a daily dosage of 20 mg, the loss of adipose tissue over 12 weeks was 1.8 kg, while after stopping the course for 3 months, only 17% of the lost fat was restored. During the study, it was found that as fat was burned, insulin sensitivity increased. This means that the body became able to cope with less of this hormone in response to the entry of food substrates into the blood, and the risk of converting glucose into fat decreased.

Pharmacodynamics and pharmacokinetics

According to Wikipedia and the Internet resource Sportwiki, Oxandrolone is an anabolic steroid with moderate anabolic and weak androgenic effects.

The substance was synthesized in the 50s of the 20th century and released in the United States of America in 1964 under the brand name Oxandrolone Anavar.

The active component is a derivative of dihydrotestosterone , the second carbon atom in the molecule of which is replaced by oxygen, and methylation on the 17th carbon atom.

The drug has virtually no toxic effects on the liver and does not exhibit pronounced androgenic effects. Due to the fact that the substance is not able to aromatize and convert into estrogens gynecomastia does not develop when taking the medicine .

Penetrating into the cell nucleus, Oxandrolone activates the synthesis of DNA , RNA structural proteins, activates cellular respiration, ATP and the accumulation of various macroelements . The substance has the ability to inhibit catabolic processes caused by taking glucocorticosteroids .

During a course of oxandrolone, muscle mass increases significantly, deposits in fatty tissues decrease, and the body begins to better absorb calcium.

The average duration of exposure of the product to the body is from 8 to 12 hours. Remnants of the active substance can be detected in the body within 45 days after completing the course.

How to take Oxandrolone

The prescription of a steroid drug, the development of a regimen of use and the duration of the course are made by the attending physician. Self-use is fraught with the development of side effects and negative consequences for the health of the body (systematic abuse of the drug can cause, for example, testicular atrophy). During treatment, the functioning of the endocrine system is reconstructed, so after completion of the course, rehabilitation therapy with the use of Tamoxifen or other drugs that inhibit peripheral estrogen receptors is sometimes necessary.

The average daily dosage, depending on the goals of treatment and diagnosis, ranges from 5 to 20 mg, divided into two to four doses. During therapy for the purpose of gaining muscle mass, Oxandrolone is taken alone or in combination with other drugs to increase efficiency. The recommended course duration is one month; treatment can be repeated no earlier than after 30–60 days.

Women

The use of hormonal drugs from the group of anabolic steroids by women can lead to the appearance of signs of virilization - the manifestation of such “male traits” as deepening of the voice, growth of hair on the body and face according to the male principle, etc. When using Oxandrolone within the recommended therapeutic doses, virilization is practically excluded, therefore the drug is safe for women, and can in rare cases be prescribed even to adolescents if the intake is strictly monitored and the doctor’s instructions are followed.

Oxandrolone for girls is prescribed in a reduced dosage (compared to “male” doses); the daily dose depends on the goals of therapy and the characteristics of the body. Reception begins with 5 mg/day, every 7–10 days a slight increase in the daily dose is made in the absence of side effects and the presence of an effect. The duration of therapy can be from one and a half to three months. If the menstrual cycle is disrupted, signs of masculinization or virilization appear, or other side effects associated with changes in hormonal levels appear, discontinue use.

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For men

Use for the purpose of gaining muscle mass, increasing endurance and strength should be done only as prescribed by a doctor and in strict accordance with his recommendations. This is especially true for combined courses, when several anabolic steroids are taken in parallel. The use of the drug solo is carried out in compliance with the following principles:

1. The duration of treatment should not exceed 6–8 weeks; it is determined individually and adjusted in accordance with the body’s response to therapy.
2. Begin therapy with a daily dosage of 20 mg, divided into two parts - in the morning, on an empty stomach, and in the morning, before lunch, at least 2 hours after the first dose.
3. The dosage is gradually increased, by an average of 20 mg every week. The daily norm is divided into three doses. The maximum daily dose cannot exceed 80 mg/day.
4. In the absence of side effects, the course is continued for 42–56 days.
5. After finishing the treatment, they are examined to determine the level of production of their own testosterone, and if necessary, they take a course of a drug that restores its secretion.

Combined course

The joint course, to increase the effectiveness of treatment and reduce side effects such as decreased libido, erectile dysfunction, toxic effects on the liver, includes other androgenic drugs - Sustanon, Primobolan, Gonadotropin, testosterone drugs. The average daily dosage of Oxandrolone in combined courses is about 40 mg/day. As part of such courses, there is a greater increase in muscle mass. It is necessary to follow a sports nutrition regimen and a special diet.

Joint reception

This course includes:

• "Oxandrolone" - 100 tablets;
• "Stanozolol" - two bottles of 10 milliliters;
• "Clomid" - 20 tablets, used after a course of therapy.

So, how to take Oxandrolone and Stanozolol together? The course starts on Monday - it’s easier to navigate. The suggested doses are small and therefore suitable for beginners.

"Oxandrolone" is used:

• in the 1st week - 2 tablets per day;
• on the 2nd - 3 tablets per day;
• on the 3rd - 4 tablets per day;
• on the 4th - 3 tablets per day;
• on the 5th - 2 tablets per day.

You don’t have to split the daily dose; you need to drink the drug at one time. But it would be more correct to divide the daily dosage into several doses. The tablets themselves can be taken at any time with plenty of liquid. The drug should be used every day, regardless of training.

Stanozolol is used in parallel with Oxandrolone. Reception also starts on Monday. The drug should be injected three times a week: on Monday, Wednesday and Friday (one ampoule each). On training days, the injection is given either an hour before the start or in the evening after training.

Almost all anabolic steroids are injected only intramuscularly, most often into the buttock. Professional athletes who are exposed to intense training loads use a different method. They inject the drug into specific muscles. This is done to obtain maximum results, because the product immediately goes to the right place. In this case, it is best to insert half a cube into one and the other hand. Before the injection, shake the ampoule well so that the active substance is completely dissolved. Beginners are advised to find an experienced person who will show the correct injection site.

Side effects

Taking the medication can cause a number of side effects associated with restructuring the endocrine system, changes in hormonal levels, and the body's individual response to therapy. The toxic effect of the drug on the liver is negligible. Studies show that using the drug at a dose of 20 mg per day for 12 weeks has no effect on the level of liver enzymes (indicators of liver destruction). The first signs of liver damage are pain in the right hypochondrium, light-colored stools and dark urine. Possible side effects include:

• reactions from the digestive system: nausea, vomiting, epigastric pain, loss of appetite, stomach problems, diarrhea;
• aching in the bones of the limbs;
• decreased libido;
• swelling;
• development of carcinoma;
• jaundice;
• development of atherosclerosis
• increased likelihood of internal bleeding;
• from the nervous system: sleep disorders, insomnia, depression;
• gynecomastia (enlargement of the mammary glands) or reduction in the size of the mammary glands;
• priapism;
• prostate hypertrophy;
• prostate adenocarcinoma;
• convulsions;
• polyuria;
• pollakiuria;
• disruptions of the menstrual cycle in women;
• phenomena of virilization in women - lowering the timbre of the voice, increasing the size of the clitoris, hair loss.

Contraindications

The medicine is not prescribed for a number of diseases and conditions associated with dysfunction of the prostate, liver, cardiac dysfunction, and endocrine system. Contraindications for use include:

• prostatitis in acute or chronic form;
• prostate cancer;
• BPH;
• breast cancer in men;
• pregnancy, lactation period;
• diabetes;
• heart failure;
• liver diseases;
• history of myocardial infarction;
• age under 18 years;
• hypersensitivity to the components of the drug;
• hypercalcemia.